Unfortunately, many 1H-NMR spectra are severely overlapped due to the multiplet structure caused by ... with no muliplet structure. The number of signals typically decreases by almost an order of ...

An NMR signal must be substantially bigger than the noise level to investigate. A minimum requisite for an S/N level might be 3:1. In standard 1 H NMR experiments of small organic molecules.

Image Credit: Nanalysis Corp. In the amide, N,N–dimethylacetamide (DMA), two different signals are observed on the 1 H NMR spectrum as two methyl groups bond to the nitrogen (Figure 1).