Scientists used advanced cryo-EM imaging to reveal how glutamate activates brain receptors, paving the way for new ...

Discover how the brain's most abundant neurotransmitter, glutamate, is revolutionizing psychiatry and offering new hope for ...

More information: Federico Miguez-Cabello et al, GluA2-containing AMPA receptors form a continuum of Ca 2+-permeable channels, Nature (2025). DOI: 10.1038/s41586-025-08736-2 ...

Its landing place on neurons is a channel called an AMPA receptor, which interacts with glutamate, and then acts like a pore that takes in charged particles. The ebb and flow of charged particles ...

The AMPA group of brain receptors have mostly been assumed to be calcium impermeable and so were not thought to contribute to the calcium-dependent mechanisms underlying learning and memory.

Box 1 | Rapid alterations in AMPAR distribution during LTP and LTD. The discovery of proteins that directly bind to AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid) receptor (AMPAR ...

These synapses were dubbed "silent" because they lacked a specific type of receptor known as “AMPA receptors,” to which glutamate binds. Evolution of Understanding Initially, silent synapses ...

The researchers discovered that tiny protein structures on brain cells, known as AMPA receptors, can transport calcium. While previous research had suggested that disruptions in calcium signalling ...

Sea's molecules act as selective dual AMPAR (AMPA receptor), KAINR (kainate receptor) antagonists (DAKAs). DAKAs dampen the activity of the excitatory neurotransmitter glutamate which plays an ...

Its landing place on neurons is a channel called an AMPA receptor, which interacts with glutamate, and then acts like a pore that takes in charged particles. The ebb and flow of charged particles ...