二甲双胍通过AMPK信号通路上调小异二聚体伴侣（SHP），SHP进而与转录因子CREB直接作用，阻止CREB对CRTC2的招募，从而下调糖异生基因的表达 8 ...

Lithocholic acid (LCA), a metabolite induced by calorie restriction (CR), activates AMPK and mimics anti-aging benefits. A ...

What’s the secret behind calorie restriction’s health benefits? Meet LCA, a powerful molecule improving energy, muscle health ...