本期推荐：为揭示2型糖尿病(T2D)增加阿尔茨海默病(AD)风险的机制，Antaros Medical团队采用[18 F]FDG/[18 F]FTHA PET、ASL-MRI和 1 H-MRS多模态成像技术，发现T2D患者存在脑葡萄糖摄取降低、白质脂肪酸摄取升高及脑血流且APOE-ε4携带者呈现相似代谢异常，为AD早期干预提供新 ...

结果发现 APOE ε4 携带者伴记忆衰退时，β 淀粉样蛋白（Aβ）积累和灰质（GM）萎缩更明显，该研究有助于优化早期干预策略。 阿尔茨海默病（Alzheimer’s disease，AD）是一种常见的进行性神经退行性疾病，也是导致痴呆的主要原因。它的发病机制复杂，有着多样的 ...

"Despite over three decades of dedicated research, the precise mechanism by which the APOE ε4 allele elevates the risk of Alzheimer's disease and related dementias remains elusive. The complex ...

Researchers examined the connection between these activities and cognitive functioning, with a focus on the apolipoprotein E (APOE) ε4 allele—a genetic risk factor for Alzheimer's disease ...