which are topographically distinct from the acetylcholine binding site, allows selective modulation of a particular muscarinic receptor subtype to be achieved. Using an assay that is based on ...

We examined the influence of rapacuronium on acetylcholine (ACh) binding to and activation of individual subtypes of muscarinic receptors expressed in Chinese hamster ovary cells to determine its ...

The crown jewel of the acquisition was seen as emraclidine, an allosteric modulator that selectively targets the muscarinic acetylcholine 4 receptor subtype. It was seen as a potential next ...