Purpose: The chemical interactions that cause drug incompatibility in solutions, with emphasis on the acid-base and ionized-nonionized forms of organic, weak, electrolyte drugs, are examined.

Neutralisation is the reaction of an acid with a base that results in the pH moving towards seven. It is a useful process that occurs in everyday life such as in the treatment of acid indigestion ...

Most organic drugs contain one acid group, usually a carboxylic acid, -COOH, or one basic primary, secondary, or tertiary amino group, NC 1-3, [3,22,27,28,29] that determines the acid-base ...