The 'fight or flight' hormone adrenaline — which is produced during times of stress — is an agonist of the β 2-adrenergic receptor (β 2 AR), a G-protein-coupled receptor (GPCR) that mediates ...

Major beta blocker mortality trials in chronic heart failure: a critical review. Heart. 1999;82(suppl 4):IV14 IV22. Altered adrenergic receptor sensitivity due to polymorphic variation.

Beta-blockers antagonize beta-1 and beta-2 receptors which are the usual targets of the sympathetic nervous system, including epinephrine and norepinephrine. This results in a decreased heart rate ...

Adrenergic receptors present in the mammalian cardiac muscle are now thought to belong to the beta type, and to initiate stimulation when occupied. Isoprenaline 2 is the catecholamine which best ...

There are three beta-adrenergic receptors—β1, β2, and β3—that perform numerous functions across the body, primarily to relay signals from the sympathetic nervous system to various tissues.

Churchwell said the drug class slows the heart by inhibiting and binding to beta one and beta two receptors on the heart. They limit the production of epinephrine, norepinephrine, adrenaline and ...