【导读】透明细胞肾细胞癌（ccRCC）是肾细胞癌最常见的组织学亚型，其肿瘤生长和转移与预后相关。4月2日，山东大学研究团队在期刊《Cell Death&Disease》上发表了研究论文，题为“NAT10 promotes the ...

胆管癌（CCA）预后差，缺乏有效治疗手段。研究人员开展了异鼠李素（Iso）对 CCA 作用的研究。结果发现 Iso 可通过 PI3K/AKT 通路抑制 CCA 细胞增殖、侵袭和转移，AKT1 可能是其治疗 CCA 的靶点，为 CCA 治疗提供新方向。

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

Mutations in the oncogene KRAS are widespread in several human cancers, including pancreatic ductal adenocarcinomas (92%), colorectal carcinomas (49%) and lung adenocarcinomas (35%). These mutations ...

The review explores how signaling disruptions inside tumor cells are often behind these setbacks. The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR ...