Medically reviewed by Mary Choy, PharmD It can be surprising to learn that a medication you’re taking for one condition may also be used to treat something completely different. One such medication is ...

However, during the run-in period, one patient had to discontinue therapy because of serious hyperkalemia (serum potassium level 6.5 mmol/l) and another stopped treatment as a result of ...

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water. Normally ...

This process is influenced by hormones such as aldosterone, which increases potassium excretion, and is also affected by the body’s acid-base balance. Finally, any excess potassium that is not ...

Aldosterone also promotes potassium and magnesium depletion, which is potentially proarrhythmic. Aldosterone was originally thought to be blocked by ACE inhibitors. However, it is now known that ...

Potassium and renal function must be routinely assessed to minimize the risk of life-threatening hyperkalemia. This review discusses the role of aldosterone antagonists in the treatment of heart ...

Aldosterone might have a role in the progression ... greater in the spironolactone group (P = 0.004). Increases in serum potassium levels, however, were seen in spironolactone-treated but not ...