The first recipient of a gene-edited pig kidney died from cardiac causes 52 days after xenotransplantation. The world's first ...

I present the evidence that renal dysfunction is a common and powerful cardiovascular risk factor and that treatment strategies intervening in the renin–angiotensin–aldosterone system can be ...

Aldosterone is known to bind to these receptors in the kidney and cardiovascular system, increasing blood pressure through increasing sodium reabsorption and probably other mechanisms. The drug is ...

High blood pressure affects one in three adults, of whom a hormonal condition called primary aldosteronism accounts for one ...

The body retains more water and salt when kidney function declines, leading to Edema in the extremities. The hormonal axis involved in this process includes angiotensin, aldosterone, and ADH ...

Pathophysiology of hepatorenal syndrome-acute kidney injury ... including the renin–angiotensin–aldosterone system, sympathetic nervous system, and arginine vasopressin, are activated to ...

Doctors at Queen Mary University of London, Barts Health NHS Trust, and University College London have led the development of ...

Baxdrostat is a drug that reduces aldosterone levels in the body to treat high blood pressure and other conditions. It's an ...

CEO Jon Congleton highlighted the company's focus on advancing its pivotal trials for lorundrostat, targeting dysregulated aldosterone in patients with uncontrolled and resistant hypertension. He ...

Anticipate topline data from pivotal Advance-HTN trial in March 2025 and pivotal Phase 3 Launch-HTN trial in mid first half of 2025 – – Completed enrollment in Explore-CKD Phase 2 trial and anticipate ...