Quaternary structure formation (assembly) and β-sheet formation appear to be linked, as is typically the case for amyloid fibril formation from unstructured peptides. The strength of the paper is ...

Unlike other amyloid fibrils, polyQ structures lack ... This fingerprint allows for precise characterization of the fibril structure and offers potential targets for diagnostic imaging.

In this case, they are homogeneous and have the same structure. Yet ... i.e. a stacking of different proteins within the same amyloid fibril," said Stanislav Bondarev, co-author of the study ...

For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...