Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed th ...

An illustration depicts cells in an Alzheimer’s-affected brain, with abnormal levels of beta amyloid protein clumping together to form plaques that collect between neurons and disrupt cell function.

The drug, gantenerumab, was abandoned by its developers, but subsequent anti-amyloid drugs lecanemab ( Leqembi) and donanemab ...

Although there are many outstanding questions about Alzheimer’s and a significant lack of effective drugs, scientists believe a protein called amyloid-beta plays an important role in the condition.

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...

Acumen Pharmaceuticals has concluded enrolment for its multi-centre, double-blind Phase II ALTITUDE-AD trial of humanised ...

Researchers from Northwestern University suggest that enhancing the brain’s immune cells may better equip them to clear out harmful clumps of the toxic protein amyloid beta, a hallmark of ...

Fukumoto, 2002 Formulation: 50 tests: This kit stains Aβ40 or Aβ42 in tissue section by the monoclonal antibodies that detects the portion of C-terminal of Aβ.

The researchers measured the concentrations in the blood of the beta-amyloids Aβ1-40 and Aβ1-42 as well as the enzyme ... while the values of the amyloid-degrading enzyme rose.

Effects of alcohol on phagocytosis were determined by uptake of oligomeric amyloid beta. RESULTS ... the uptake of amyloid beta1-42, by primary microglia, was reduced by alcohol.

Cerebrospinal fluid was analyzed for key biomarkers of Alzheimer’s disease, including total tau (tau), phosphorylated tau ...