In Alzheimer's disease (AD), amyloid β-protein (Aβ) production by regulated intramembrane proteolysis is crucial for pathogenicity. An unusual intramembrane cleavage generates various Aβ ...

Panelists discuss how amyloid-targeting therapies for Alzheimer disease represent a breakthrough drug class that works by binding to and removing beta-amyloid plaques through various mechanisms ...

Although there are many outstanding questions about Alzheimer’s and a significant lack of effective drugs, scientists believe a protein called amyloid-beta plays an important role in the condition.

That view is informed by data on the first wave of successful anti-amyloid-beta antibodies. Roche is hoping to improve on those molecules by pairing its antibody with technology for crossing the ...

Unlike amyloid-beta plaques, another characteristic of ... biochemical and molecular biology techniques to identify a core sequence of tau protein, called tau258-368, which is crucial for NFT ...

"These exciting preliminary findings hint very clearly at the potential role of lowering beta amyloid in prevention of Alzheimer's disease," said Maria C. Carrillo, Ph.D., Alzheimer's Association ...