sAPPα is a secreted peptide produced from APP processing along the "non-amyloidogenic" pathway. Meta-analysis did not show a statistically significant difference in the levels of sAPPα in the plasma ...

According to the study, both neurons and OLs were found to express amyloidogenic pathway genes. APP expression in OLs was confirmed in both murine and human tissues. Novel AD mouse lines revealed ...

The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal ...