Girolline, a compound extracted from the sea sponge Pseudaxinyssa cantharella, has been investigated for possible antitumor effects and also found to have anti-malarial effects. Now, researchers have ...

Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism ... inhibition of upstream receptors increases their ...

14 release. Doing so is meant to engage several antitumor signaling pathways at once, according to the release, which could lead to greater efficacy than current treatments. “Partnering with ...

This approach, which proposes a dual attack against the tumor, has shown promising results in preclinical models, achieving a complete and long-lasting antitumor response in mouse models with ...

It was initially thought that girolline's possible antitumor effect was due to its ... by the ribosome-associated quality control (RQC) pathway, which degrades the protein that is under production.