In both instances, GFAP intermediate filaments are still formed, but their presentation in the astrocyte elicits fundamental changes in cell function, through perturbation of the cytoskeleton.

Relatively unknown brain cells—"astrocytes"—are believed to play an important role. At the Uppsala Biomedical Center, lab researchers are attempting to learn more about their function in order ...

Dementia is a serious condition that affects millions of people worldwide, leading to memory loss, confusion, and ...

The potential effects of astrocyte dysfunction in neurodegenerative ... been hypothesized to result from the failure of astrocytic functions that require cell–cell coupling to maintain their ...

Like neurons, astrocyte processes are decorated with receptors and transporters for numerous neurotransmitters, allowing astrocytes to sense and regulate multiple aspects of brain function. Unlike ...

Since such experimental pipelines to analyze various astrocytic functions are currently unavailable, therapeutic development using iPSC-derived astrocytes has been limited. Therefore, in this ...

Astrocytes, star-shaped cells, play an essential role in supporting neurons and maintaining brain health. While their function in gray matter is well-documented, their diversity in white matter ...

“During development, neural stem cells generate neurons first and later go on to produce astrocytes. So, they are from the same lineage. If you want to introduce a cell fate switch, the closer ...

Our lab is interested in the cellular and molecular mechanisms that define and regulate the diversity of astrocyte function in the intact and injured or diseased CNS. We use mouse genetics to ...

Get Instant Summarized Text (Gist) The study identifies distinct subtypes of white matter astrocytes, including a unique type with regenerative potential. Using advanced sequencing techniques ...