In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

AMPK signaling promotes an increase in cell stiffness that drives entotic ingestion into winners (Fig. 2). AMPK signaling is also well known to activate the nutrient recycling mechanism autophagy. We ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

We have observed implantation defects and thus, reduced fecundity in conditional knockout mice models of the autophagy-related proteins in the reproductive tract. In the absence of these proteins, we ...