而 B7-H 家族作为免疫调节网络的重要组成部分，包括 B7-H2（ICOSL）、B7-H3、B7-H4、B7-H5（VISTA）、B7-H6 和 B7-H7（HHLA2）等成员，在肿瘤免疫调节中发挥着多样且关键的作用，为癌症免疫治疗带来了新的契机。 B7-H 家族：肿瘤免疫与治疗的关键调节因子 B7/CD28 超家族 ...

AZD8205 is a topoisomerase 1 inhibitor (Top1i) ADC that targets B7-H4, an immunoregulatory protein that is highly expressed in some solid tumors but has limited expression in normal tissue.

Funda Meric-Bernstam, M.D., Chair, Investigational Cancer Therapeutics AZD8205 is a topoisomerase 1 inhibitor (Top1i) ADC that targets B7-H4, an immunoregulatory protein that is highly expressed ...

Opens in a new tab or window Puxitatug samrotecan (P-Sam), an investigational antibody-drug conjugate (ADC) targeting B7-H4-expressing tumors, showed promising efficacy in patients with advanced ...