The reward for unlocking the mysteries of DNA repair could be significant. For instance, women with defective versions of the BRCA repair proteins have a much higher risk of aggressive breast and ...

His team discovered that, when functioning properly, BRCA2 helps to repair a specific kind of DNA damage called double-strand breaks. Without it, cells make imperfect repairs, introducing the ...

Homologous recombination plays essential roles in the repair ... stranded DNA with the filament (green and brown), while the other is sequestered away (red). The non-homologous part of the DNA is ...

The National Institute for Health and Care Excellence (NICE) has given a positive recommendation for Lynparza (olaparib) for ...

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other copy is inactivated by an inherited mutation. This means that a total ...

“The surprising result of our research is that DNA repair, which normally protects healthy cells ... The team also found that ...

Advances in DNA sequencing technologies in the 1990s allowed a team working in the US to identify the BRCA1 gene by sequencing DNA from families with high rates of breast cancer and identifying ...

The screening programme looks for mutations in the BRCA genes which push up a person’s risk of cancer. Everyone has BRCA1 and BRCA2 genes, but people who have changes in the gene are at higher ...

But, new research has discovered a method to isolate those dangerous mutations, thereby finding a way to fix them. When BRCA1 ...

That's because she has a gene mutation called BRCA1, which affects around one in every 300-400 people. This is her story in her own words. Hayley Minn Hayley's grandmother died of breast cancer ...

"It's an all-or-none kind of pattern: A family with three daughters who all have ovarian cancer is more likely to be driven by inherited X mutations than by BRCA mutations." Dr Catherine Pickworth ...