Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other copy is inactivated by an inherited mutation. This means that a total ...
“The surprising result of our research is that DNA repair, which normally protects healthy cells ... The team also found that ...
His team discovered that, when functioning properly, BRCA2 helps to repair a specific kind of DNA damage called double-strand breaks. Without it, cells make imperfect repairs, introducing the ...
While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...
But, new research has discovered a method to isolate those dangerous mutations, thereby finding a way to fix them. When BRCA1 ...
Homologous recombination plays essential roles in the repair of DNA ... homologous part of the DNA is un-opened (purple). Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, ...
How do tumor cells die after radiotherapy- one of the most important type of cancer treatment- is one of the big mystery in ...
Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms ... end resection in BRCA-deficient ...
While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade ...
That's because she has a gene mutation called BRCA1, which affects around one in every 300-400 people. This is her story in her own words. Hayley Minn Hayley's grandmother died of breast cancer ...
We identified the breast cancer gene BRCA2, which enabled families with a history of breast cancer to be assessed for future risk, and laid the groundwork for developing novel forms of therapy for ...