Right now, women with BRCA1 alterations can opt for watchful ... through a constellation of genes that monitor cells for DNA damage, repair DNA breaks or, when all else fails, tell defective ...

During the DNA damage response (DDR), repair proteins such as the E3 ubiquitin ligase BRCA1 accumulate at DNA double-stranded breaks (DSBs), and ubiquitylation at these sites helps recruit further ...

DNA damage is a natural occurrence in cells caused ... homologous recombination deficient cancer types—for example, the BRCA1 and BRCA2 mutations," said Qingshu Meng, Ph.D., a postdoctoral ...

Mutations in the genes BRCA1 and BRCA2 can impair the body's ability to repair damage to DNA in its cells. This can greatly increase the risk of developing cancers. On average, women have a 2% ...

DNA damage is the basic cause of cancer -- but ... Patients with genetic alterations in the DNA repair genes BRCA1, BRCA2 or ATM who received olaparib had a median overall survival of 19.1 months ...