The men had either been tested for germline (166), somatic (280), or both types (four) of genetic variants of BRCA1, BRCA2, ATM, CDK12, and PALB2 genes, with a view to starting them on PARP ...

People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of them doesn't function. For cancer-suppressor genes like BRCA1 ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

The breast cancer susceptibility gene 1 (BRCA1) protein forms complexes with other protein components to regulate the cellular response to DNA damage. Three studies now report the identification ...

Paige More got a preventive double mastectomy at age 24 after learning she was positive for the BRCA1 gene, and says it was the best decision she ever made Julie Mazziotta is the Senior Sports ...

For example the BRCA1 and BRCA2 genes that can contribute to breast cancer. Mutations in these genes account for approximately 10% of all inherited breast cancer cases detected. Scientists ...