Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other copy is inactivated by an inherited mutation. This means that a total ...

The product of a sixth, newly-cloned FA-associated gene has been linked to BRCA1, and may finally offer some insight into the mechanism by which FA increases cancer susceptibility. You have full ...

Germline BRCA1 and BRCA2 mutations are responsible for approximately 52% and 32% of hereditary breast cancer cases, respectively, and patients carrying these mutations have a 50% chance of passing the ...

Patients with genetic alterations in the DNA repair genes BRCA1, BRCA2 or ATM who received olaparib had a median overall survival of 19.1 months, compared with 14.7 months for those on targeted ...

Germline BRCA1 and BRCA2 mutations account for 5% to 10% of all breast cancers ... Olaparib is a precision medicine and PARP inhibitor that disrupts the DNA-repair process in cancer cells, helping to ...