Although only the second approach yielded a high-resolution structure (2.3 Å ... active receptor mutants and biased receptor mutants that signal via one or the other signaling pathway may ...

Major beta blocker mortality trials in chronic heart failure: a critical review. Heart. 1999;82(suppl 4):IV14 IV22. Altered adrenergic receptor sensitivity due to polymorphic variation.

Shenoy et al., "β-Arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor," J Biol Chem, 281:1261-73, 2006. (Cited in 50 papers) The finding: In 2005, while screening ...

Such patients may be less responsive to positive inotropic agents, whereas the beneficial effects of nesiritide, which are not dependent on the β-adrenergic receptor signal-transduction pathway ...