Using unnatural base pairs, researchers have site-specifically biotinylated RNA, allowing them to immobilize an aptamer on a chip and detect its interaction with a target protein. Experiments with ...

(B) Oxidation/Biotinylation. The cap structure is oxidized with sodium peroxide and biotinylated with biotin (long arm) hydrazine. (C) RNase I digestion. Single strand RNA is digested with RNase I.