During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar organization of microtubules, which have biochemically ...

bipolar, microtubule-based mitotic spindle is assembled de novo. The spindle functions not only to segregate the replicated chromosomes into separate nuclei (karyokinesis), but also ensures that a ...

Successful chromosome separation requires the attachment of the bipolar mitotic spindle to each of the sister chromatids. To ensure reliable segregation and the equal division of chromosomes ...

Mitotic spindles are dynamic, self-organizing, intracellular structures that are essential for cell division. Spindles are composed of proteins, cytoskeletal elements and microtubules, which are a key ...

The mitotic spindle is a bipolar structure that extends from the two spindle poles (centrosomes in animal cells).

It has been known for decades that chromosomes attach to a bipolar structure called the mitotic spindle that is composed of microtubules. Mitosis is the process by which a cell divides its nucleus ...