The blood-brain barrier has confounded the development ... charge and lipid solubility of a compound to facilitate BBB transport. The apical sides of endothelial cells, which face the blood ...

The blood–brain barrier is the biggest challenge to the development of drugs that target the CNS. Most capillary beds leak plasma contents between and across endothelial cells by way of window-like ...

vaccination, lung and skin disease since they were first discovered by British haematologist Alec Bangham, FRS in 1965.” The paper ‘Selective Liposomal Transport Through Blood Brain Barrier Disruption ...

is a passive impermeable barrier that segregates blood and brain interstitial fluid has given way to the concept that the BBB is a dynamic conduit for transport between the blood and the brain for ...

Scientists from the University of Liverpool and their global collaborators have highlighted the most effective treatments for ...

The brain is the only organ to have its own security system: a tightly packed network of blood vessels and barriers that allow the entry of ... shows that liposomes can potentially transport ...

The blood–brain barrier is a highly selective shield that protects the brain from harmful substances in the bloodstream.

Researchers have identified a novel mechanism by which immune cells wiggle their way across the blood-brain barrier in diseases such as multiple sclerosis (MS). A type of T-cell involved in autoimmune ...

"The brain still needs to absorb nutrients from the blood, so the barrier contains specialized cellular machines—called ...

Scientists from the University of Liverpool, and their global collaborators have highlighted the most effective treatments ...

In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...