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生物通
18 天
基于生物流体的阿尔茨海默病分期研究:探索疾病进程的新视角
通过确定生物标志物异常阈值,划分出 4 个 CSF 分期。Aβ 阴性参与者多为 0 期,认知未受损 Aβ 阳性(CU+)参与者各期分布相似,轻度认知障碍阳性(MCI+)和 AD 组中双阳性和三阳性病例增多。tau-PET Braak 0 组主要是 0 期个体,随着 Braak 阶段推进,生物标志物阳性 ...
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