Theoretically, adding the ARB after the ACE inhibitor may have little effect on bradykinin levels, whereas adding the ARB before the ACE inhibitor may heighten the bradykinin effect of the latter.

Jacobson followed this abnormal RAS in the lung fluid samples to the kinin cascade, an inflammatory pathway that is tightly regulated by the RAS. He found that the kinin system—in which a key peptide, ...

As angiotensin-II is subtracted from this hemodynamic equation, there can be a precipitous fall in BP, which is only worsened by the actions of the vasodilator bradykinin. ACE inhibitor-related ...