Drugs in this class also decrease ACE-dependent degradation of substance P and bradykinin, two proinflammatory mediators that are believed to be involved in the pathogenesis of CRPS. Genetic and ...

Jacobson followed this abnormal RAS in the lung fluid samples to the kinin cascade, an inflammatory pathway that is tightly regulated by the RAS. He found that the kinin system—in which a key peptide, ...