慢性 GVHD 中，巨噬细胞则倾向于 M2 表型，虽然 M2 巨噬细胞有助于组织修复，但也可能促进纤维化，导致器官功能障碍。比如，M2 巨噬细胞与 CD4 + 细胞和成纤维细胞的相互作用，会促进慢性 GVHD（cGVHD）中的组织纤维化 。 巨噬细胞还与其他免疫细胞相互作用 ...

Using a xenogeneic model of GvHD in NOD/SCID/γc− (NSG ... FITC anti-mouse CD45, FITC anti-human CD4, FITC anti-human CD14, PE anti-mouse CD45, PE anti-human CD8, PE anti-human CD19, PE anti ...

Whereas prior acute GVHD impaired Treg reconstitution, Treg subsets (absolute numbers and frequencies relative to CD4 + T-cell subsets) at 3, 6 and 12 months after HSCT were not associated with ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Effective across T-Cell types: Works with both CD4 and CD8 T cells ... Reduced autoimmunity: Minimal risk of graft-versus-host disease (GVHD). - One-time infusion: Provides a lasting impact ...