编辑丨王多鱼排版丨水成文抗 PD-1 联合仑伐替尼（lenvatinib，一种多靶点受体酪氨酸激酶抑制剂）治疗在多种肿瘤中均显示出临床疗效，但潜在的免疫学机制尚不清楚。2025 年 1 月 30 ...

The median absolute counts of CD3 +, CD4 +, and CD8 + cells significantly decreased at 12, 24, and 48 weeks in both the HBsAg clearance and persistence groups, returning to baseline at 72 weeks ...

点击蓝字关注我们神经性疼痛作为最顽固的慢性疼痛类型，在女性中的患病率显著高于男性。性别依赖的神经免疫机制是神经损伤引起的异常性疼痛的基础。动物实验表明小胶质细胞介导雄性慢性疼痛的发生过程，而适应性免疫系统介导雌性疼痛反应。Panx ...

CD4-positive T cells are a subtype of lymphocyte ... have altered cholesterol metabolism, and induce CD8 + T cell senescence to dampen anti-tumor immunity. Regulatory T cells play critical ...

调节性T细胞是维持机体免疫稳态的CD4+ T细胞亚群，也是肿瘤微环境中免疫抑制屏障的主要构成细胞。因此，特异性地调控肿瘤微环境的Treg细胞使其功能与稳定性发生改变，将能够促进肿瘤杀伤反应的发生。

Typically, in advancing disease, as the immune system becomes exhausted, it is less able to produce T-cells to defend itself. The CD4/CD8 percentage helps healthcare practitioners see this.

Figure 1: γ c-dependent lymphokines are required for the peripheral survival of naïve CD4 + T cells. Figure 3: Antigen-driven proliferation of CD4 + T cells is independent of γ c-cytokines.

CD4-cell counts and T-cell activation levels were determined ... and higher LPS levels were associated with greater activation of CD8 + lymphocytes. CD8 + activation also was found to be higher ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...