For example, monoclonal antibody against CD154 prevents the induction of autoimmune disorders in many animal models 7,8,9,10 and also ameliorates established diseases 11. Disrupting CD154–CD40 ...

In contrast, after adding 20 mg/kg of monoclonal antibody against CD40 ligand to the regimen on days 0 and 2, we observed four thromboembolic complications in nine recipients. These included two ...

CD40 agonistic antibodies mimic the natural interaction between the CD40 receptor and its ligand, CD40L, triggering immune responses through cytokine release and T-cell activation. This approach ...

Frexalimab is described by Sanofi as a ‘second-generation’ anti-CD40L antibody that can block the costimulatory CD40/CD40L cellular pathway necessary for adaptive and immune cell activation ...

“We have been researching precision medicine for close to 15 years now, as well as how we can use antibodies to influence an ...

Findings in HIV highlight AMV technology's versatility, robust immune response, and excellent safety profile, underpinning company’s expansion into oncology applications AMVs are a new class of ...