点击蓝字关注我们【导读】癌症疫苗面临的一个基本挑战,是如何产生对肿瘤抗原具有特异性的长效功能性T细胞。在这项研究中,团队发现针对体细胞突变衍生的新抗原的mRNA脂质体疫苗,可以解决胰腺导管腺癌(PDAC)的这一难题。2025年2月19日,美国纪念斯隆 ...
在癌症治疗的战场上,疫苗一直被寄予厚望,它就像一位英勇的战士,肩负着对抗癌症的重任。然而,现实却给这位战士设置了重重障碍。其中一个最棘手的问题就是,如何让癌症疫苗产生长期存活且功能强大的 T 细胞(一种在免疫系统中发挥关键作用的白细胞,能识别和攻击异常细胞),而且这些 T 细胞还得精准地针对肿瘤抗原。这就好比要训练出一批神枪手,不仅要百发百中,还得能长时间坚守岗位。
Immune cell populations of people with post-vaccination syndrome had lower levels of effector CD4 T cells and higher levels ...
The phase 1 trial results, published Feb. 19 in Nature, evaluated the personalized mRNA neoantigen vaccine autogene cevumeran in combination with surgery, immunotherapy drug atezolizumab and ...
Within the immune system, interleukin-15 (IL-15) plays a relevant role by boosting the number of cytotoxic T cells and NK cells, the major drivers of anticancer immune response. Researchers from Sotio ...
Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...
华东师范大学生命科学学院卢伟强研究员和刘明耀教授团队合作,在 Nature Immunology 期刊发表了题为: The lactate receptor HCAR1 drives the recruitment of ...
研究结果显示,抗生素处理会削弱模拟禁食饮食的抗肿瘤效果。于是,研究人员分析了模拟禁食饮食对肠癌小鼠模型肠菌的影响。从分析结果来看,罗伊氏乳杆菌( Lactobacillus reuteri )和假长双歧杆菌( Bifidobacterium ...
In the ongoing battle against triple negative breast cancer, Vanderbilt researchers have uncovered a promising non-invasive ...