For example, 3D structures have been determined by cryoEM [1], all exhibit a clear thermal unfolding transition [2],[3]), high ATPase activity (except for those containing ATPase incompetent mutations ...

UK MHRA approves Vertex’s Alyftrek, a once-daily next-in-class CFTR modulator to treat cystic fibrosis: London Monday, March 10, 2025, 10:00 Hrs [IST] Vertex Pharmaceuticals, a ...

CF is a chronic disease in which defects in the CFTR (cystic fibrosis transmembrane conductance regulator) channel cause a build-up of mucus in the lungs, airways and digestive system, leading to ...

In this study, we looked at the recently identified BEST4/CA7 + cells, a specific type of cell in the intestinal lining that highly expresses CFTR, an important ion channel for electrolyte balance." ...

"In this study, we looked at the recently identified BEST4/CA7 + cells, a specific type of cell in the intestinal lining that highly expresses CFTR, an important ion channel for electrolyte ...

Usually, the protein CFTR acts as a channel that helps transport chloride ions in and out of cells throughout the body. In people with CF, both copies of the CFTR gene contain variants that ...