To assess CYP3A4 induction in vivo, 18 patients with psychiatric disorders were titrated to steady-state quetiapine levels (300 mg twice daily), then titrated to 600 mg daily carbamazepine for 2 ...

The most common manifestation of pharmacokinetic interactions with warfarin involves the inhibition or induction of its ... importance of the warfarin cytochrome P450 (CYP) metabolic pathways.