Multiple molecules showed promising on-target inhibition, with one hit achieving nanomolar IC50 values without showing any sign of CYP inhibition. Optimization of that hit, named ISM001 ...

Is there anything more delicious than a cold glass of fresh grapefruit juice on a warm summer day? Unfortunately, many of you cannot partake in such a tempting treat because you're taking one of ...

Convelo Therapeutics Inc. and Genentech Inc. have identified lanosterol 14α-demethylase (CYP51A1; CYP51) inhibitors reported to be useful for the treatment of multiple sclerosis, encephalomyelitis, ...

Taking Ubrelvy with a drug known as a strong CYP3A4 inhibitor may increase your risk of side effects, such as fatigue. (“CYP” stands for cytochrome P450.) Due to this risk, doctors typically ...

The biochemistry term "suicide enzyme inhibitor" is a fairly accurate portrayal of what's going on. CYPs are your body's oxidative metabolism workhorses Here's a brief look at CYPs, starting with the ...

Shenzhen Zhongge Biotechnology Co. Ltd. prepared and tested cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) inhibitors reported to be useful for the treatment of castration-resistant ...