齐墩果酸（Oleanolic acid，OA）存在水溶性差、通透性不佳的问题，且在肠道中主要由细胞色素 P450（CYP）同工酶，尤其是 CYP3A 代谢，这导致其口服生物利用度较低。OA 具有护肝、抗炎、抗糖尿病和抗病毒等多种药理作用，但因其被归类为生物药剂学分类系统（BCS ...

Most drugs are metabolized by CYP3A enzymes, and variations in expression levels of these enzymes are believed to determine whether patients will have a positive or adverse drug response.