Cleavage of the linker releases and activates the drug payload, an optimized camptothecin with a clinically validated mode of action. Animal studies show that this two-step targeting to-, and ...

The anticancer potency of Camptotheca acuminata is attributed to camptothecin (CPT), an alkaloid scientists have isolated from the tree's bark and stems. Research revealed that this compound ...

The study, titled "Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death," was published ...

Lilly is paying $13 million upfront for exclusive rights to use ImmunoGen's novel camptothecin molecules in ADCs against drug a first batch of drug targets, with an option on a second batch that ...