Summary. Doripenem, a member of the β-lactam class of antibiotics, is the newest addition to the carbapenems. It exhibits concentration-independent bactericidal activity against gram-positive ...

These are antibiotics that are normally reserved for serious infections in hospitals. Carbapenems are effective against bacteria which have become immune to penicillins and cephalosporins. The ...

1992 and 1997: ceftibuten and cefcapene, new oral cephem antibiotics. • 2005: doripenem, a new carbapenem antibiotic. • 2019: cefiderocol, the world’s first approved siderophore ...

The carbapenem antibiotics (imipenem, meropenem and doripenem) are considered the agents of choice for A. baumannii infections. The presence of resistance to these agents constrains therapeutic ...

Both approaches require understanding of the structure and mechanism of resistance enzymes to guide development ... structural biological and computational chemistry approaches to study ...

That includes improving local data about co-morbidities that can affect the ability of antibiotics to work. Among the most important AMR targets are carbapenem-resistant bacteria. In Latin America ...

Increasing incidence of bloodstream infections with Enterobacterales resistant to carbapenem antibiotics poses a significant threat to patients and healthcare systems in the EU/EEA Furthermore ...

Carbapenem-resistant Enterobacterales (CRE ... Even though several new antibiotics are available, treatment options remain limited overall. Immediate action is essential to control this problem ...