In multicellular organisms, the total number of cells is a balance between the cell-generating effects of mitosis and cell death that is induced through apoptosis. A disruption of this delicate ...

Thus, in order totreat cutaneous malignancies such as melanoma-or squamous-cell carcinoma with recombinant Apo2L/TRAIL (ref. 7), it is critically important not to trigger premature apoptosis of ...