Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in autoimmunity.

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ. 2011 Sep; 18(9):1487-99. doi: 10.1038/cdd2011.81). Materials/Subjects and Methods: This section ...

Cells use a variety of programmed cell death mechanisms to maintain homeostasis through cellular self-destruction, including apoptosis, necroptosis, and pyroptosis. Elina is a PhD candidate at the ...

Different types of programmed cell death. This picture summarizes the different pathways of programmed cell death (Note: ROS: reactive oxygen species). By unveiling the complex interactions ...

There are many different triggers of apoptosis, but they all ultimately activate executioners called caspases. Cleaving hundreds of different kinds of proteins within a cell, these enzymes wreak havoc ...

Researchers at Moffitt Cancer Center focused on a form of cell death called necroptosis ... how well cancer treatments might work for different patients. More information: Kay Hänggi et al ...