ATR 激酶是应对 DNA 复制应激（RS）的关键调节因子，在癌细胞中，许多遗传突变会导致 RS 水平升高，而 ATR 在维持复制叉的稳定性和促进细胞存活方面发挥着重要作用。抑制 ATR 可使癌细胞因复制叉崩溃和有丝分裂灾难而死亡，因此 ATR 成为癌症治疗的潜在靶点。目前，基于 ATR 抑制剂（ATRi）的临床试验正在开展，但尚未建立有效的治疗方案。

This serves two main functions. First, it allows PARP proteins to maintain functionality by returning them to their inactive forms. PARG inhibition results in increases in sensitivity to DNA damage ...

While all poly ADP-ribose polymerase (PARP) inhibitors improved progression-free survival, olaparib significantly extended overall survival (OS), making it a preferred option.

Ovarian cancer, often called the silent killer, presents one of the most serious health threats women face globally. Its subtle symptoms frequently mimic less ...

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are promising cancer treatments because they block a cell’s ability to repair DNA damage. Four PARPis are currently approved for use in the ...

By blocking the enzyme poly (ADP-ribose) polymerase (PARP), PARP inhibitors induce cancer cell death. Hormone Therapy: Traditional hormone therapy has been a mainstay of prostate cancer treatment ...