A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a ...

In collaboration with a foundation that breeds service dogs for the visually impaired, researchers at the School of ...

New research now suggests that B cells avoid gambling away good mutations by strategically banking successful ones. As described in Nature, successful high-affinity B cells can proliferate under ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For ...

Successful high-affinity B cells can proliferate under special conditions that reduce the risk of mutation. Capturing this ...

Neurons collected from brain lesions in MS patients were found to accumulate new genetic mutations faster than healthy nerve ...

Our immune system works to fight infections immediately, but also maintain long-term immunity. Two waves of protection help ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies ...

POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

Understanding your tumor biology is key to finding the right treatment for pancreatic cancer. Identifying mutations, or changes in a [...] READ MORE ...

They also show that models learned from nonsynonymous mutations and from out-of-frame sequences are different, prompting new questions about germinal center function. Strengths of the study include an ...