The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role in cell growth and survival and is activated in various cancers. Multiple components of the pathway are frequently targeted by ...

BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the ...

Cellular reprogramming is an intrinsic evolutionary trait to constantly promote adaptations that confer survival advantage. It is also more frequent during development when organs are being formed and ...

A new review was published as the cover paper of Aging, titled "Types of cell death and their relations to host immunological pathways." Various immune pathways in the host, such as TH1 ...