基于此，西南医科大学的吴安国教授与重庆市中医院的任放副研究员，深入探讨了线粒体自噬与cGAS–STING信号通路之间的相互作用。这一研究揭示了细胞在应激状态下如何通过这些机制维持稳态。具体而言，线粒体自噬是清除受损线粒体的关键手段，而cGAS–STING ...

尤其是西南医科大学药学院的吴安国教授和重庆市中医院的任放副研究员课题组对线粒体自噬与cGAS–STING信号通路的深入研究，为我们理解神经炎症提供了新的视角。本篇文章将借此探索这些机制的互动关系以及它们在神经退行性疾病中的重要性。 1. 神经炎症的 ...

研究首次证实巨噬细胞中的cGAS-STING信号通路在良性气道狭窄中发挥重要作用，该信号通路通过诱导急性炎症促进气管纤维化。相关研究成果发表在国际学术期刊《自然·通讯》上。 良性气道狭窄由非恶性肿瘤因素引起，治疗较为复杂，严重时可能导致窒息甚至 ...

cGAS was shown to be a member of the nucleotidyltransferase family and to be capable of generating cGAMP in vitro from GTP and ATP in the presence of dsDNA. cGAMP in turn bound to and activated the ...

The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to ...

However, its precise function in response to DNA virus infection remains elusive. Herein, we find that HDAC6 deficiency promotes the activation of cGAS-STING signaling and type I interferon (IFN) ...

The recently discovered cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling in tumor-associated macrophages (TAMs) plays an important role in stimulating the antitumor ...

Background: Acute lung injury (ALI) is a severe condition characterized by inflammation, tissue damage, and persistent activation of the cyclic GMP-AMP (cGAS)-stimulator of interferon genes (STING) ...