Using cryo-electron microscopy and AI, researchers at the University of Missouri have mapped ApoB100, a key protein in LDL ...

non-HDL cholesterol (HDL-C) is a secondary target of therapy after the LDL-C goal has been achieved. Non-HDL-C concentration is highly correlated, but may be discordant with that of ApoB.

Scientists have discovered a potential new treatment for familial hypercholesterolemia, inspired by signs seen in the Mona ...

As they deliver triglyceride to tissues, the particles shrink to 18–30 nm, transitioning into LDL with cholesterol as the dominant lipid. Structural changes in apoB-100 enhance its binding to ...

non-high-density lipoprotein cholesterol (non-HDL-c), low-density lipoprotein cholesterol (LDL-c), HDL-c, triglycerides, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) were compared in newly ...

We assessed the correlation between ApoB serum levels and the different lipid measures (total, LDL and HDL cholesterol, triglycerides) with the Pearson's correlation coefficient. ApoB serum levels ...

While previous cholesterol markers just show the amount of lipid in the blood, Dr. Sniderman says, ApoB provides a direct ...

Higher total cholesterol:HDL was associated with an increased risk of ALS (HR 1.17, 95% CI 1.05 to 1.31, p=0.006). In models incorporating multiple metabolic markers, higher LDL or apoB was associated ...

This condition arises from mutations in specific genes responsible for cholesterol regulation, such as the LDLR, APOB, and PCSK9 genes. These mutations impair the body's ability to remove LDL ...

When patients are found to have elevated non-HDL cholesterol, ApoB-100 or LDL particle concentrations, they are presumed to be at increased risk and are often prescribed more aggressive lipid ...