Chromosomal instability (CIN) is a significant characteristic of many cancers, marked by the presence of large-scale changes in the number and structure of chromosomes. This instability can lead ...

Recent data, however, have suggested that microsatellite instability could be secondary to the effects of chromosomal instability. Walther et al. conducted a systematic review of all published ...

In cells with high levels of chromosomal instability (in red), activation of the apoptotic caspases (in green) plays a fundamental role in tissue invasiveness. Disclaimer: AAAS and EurekAlert!

The paper S.F. Bakhoum et al., “Chromosomal instability drives metastasis through a cytosolic DNA response,” Nature, 553:467-72, 2018. Aneuploidy—the presence of abnormal numbers of chromosomes in a ...