Chromosomal instability (CIN) is a significant characteristic of many cancers, marked by the presence of large-scale changes in the number and structure of chromosomes. This instability can lead ...
The paper S.F. Bakhoum et al., “Chromosomal instability drives metastasis through a cytosolic DNA response,” Nature, 553:467-72, 2018. Aneuploidy—the presence of abnormal numbers of chromosomes in a ...
In cells with high levels of chromosomal instability (in red), activation of the apoptotic caspases (in green) plays a fundamental role in tissue invasiveness. Disclaimer: AAAS and EurekAlert!
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