Our chromosomes are much longer than the space in which they are packaged in the cell. Chromosome compaction is on the order of several thousand fold, yet these chromosomes have to be unraveled every ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For ...

Scientists at EMBL have captured how human chromosomes fold into their signature rod shape during cell division, using a ...

Comparing the length of metaphase chromosomes to that of naked DNA ... compacting it down to less than half an inch. This level of compaction is achieved by repeatedly folding chromatin fibers ...

EMBL scientists have shown how overlapping loops of DNA stack upon each other in dividing cells to give rise to rod-shaped ...

The scientists built a computational model that allowed them to simulate the process of chromosome compaction based on a few fundamental assumptions ...

As chromosomes prepare to separate, the chromatin compacts. Chromosome compaction during mitosis requires the action of condensin proteins and post-translational modifications of histone proteins. In ...